So, I tried it out and it works fine.
It works with AMD cards & it's compatible with the Steam Overlay.
However, it locks my game to 30 FPS (sometimes reaches 40).
I think I read something about disabling depth access for a bit better performance, assuming you don't want to use DoF, AO, and so on. I'll look that up soon, though you can find it somewhere in the config files.
But yeah, many effects can hog performance. For that matter, Ambient Occlusion can tank FPS on practically any hardware, especially depending on the method.
The cheapest part of ReShade is the SweetFX/CeeJay color correction stuff. That's my mainstay. I've been addicted to that since THUGPro "alpha."